Research Papers

NIH National Library of Medicine

Smoking and pneumococcal infection.

Sheffield JV, Root RK.

N Engl J Med. 2000 Mar 9;342(10):732-4. doi: 10.1056/NEJM200003093421010.

PMID: 10706905 No abstract available.

Tumor-induced hypercalcemia.

Rudd FV, Root RK, Skoglund RW Jr, Ansell JS.

J Urol. 1972 Jun;107(6):986-9. doi: 10.1016/s0022-5347(17)61189-3.

PMID: 5033985 No abstract available.

Legislated limits for housestaff training.

Root RK, Nation CL.

Ann Intern Med. 1992 Apr 15;116(8):694-6. doi: 10.7326/0003-4819-116-8-694.

PMID: 1546872 No abstract available.

Leukocytic function in hypogammaglobulinemia.

Mickenberg ID, Root RK, Wolff SM.

J Clin Invest. 1970 Aug;49(8):1528-38. doi: 10.1172/JCI106370.

PMID: 4194088 Free PMC article.

Leukocyte adhesion proteins: their role in neutrophil function.

Root RK.

Trans Am Clin Climatol Assoc. 1990;101:207-24; discussion 224-6.

PMID: 2577246 Free PMC article. Review.

Host-defense mechanisms in hidradenitis suppurativa.

Dvorak VC, Root RK, MacGregor RR.

Arch Dermatol. 1977 Apr;113(4):450-3.

PMID: 848973

Differential white blood cell count: underutilized or overrated.

Stevens DL, Root RK, Rosen H, Dale DC.

Curr Opin Infect Dis. 2000 Jun;13(3):205-207. doi: 10.1097/00001432-200006000-00001.

PMID: 11964787 No abstract available.

Granulocyte function during lithium therapy.

Cohen MS, Zakhireh B, Metcalf JA, Root RK.

Blood. 1979 May;53(5):913-5.

PMID: 435646 Free article.

Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients.

Root RK, Dale DC.

J Infect Dis. 1999 Mar;179 Suppl 2:S342-52. doi: 10.1086/513857.

PMID: 10081506 Review.

Myeloperoxidase deficiency: prevalence and clinical significance.

Parry MF, Root RK, Metcalf JA, Delaney KK, Kaplow LS, Richar WJ.

Ann Intern Med. 1981 Sep;95(3):293-301. doi: 10.7326/0003-4819-95-3-293.

PMID: 6267975

Community-acquired Acinetobacter calcoaceticus var anitratus pneumonia.

Goodhart GL, Abrutyn E, Watson R, Root RK, Egert J.

JAMA. 1977 Oct 3;238(14):1516-8.

PMID: 70540

Host defenses against infection: importance of phagocytic mechanisms from the study of genetic disorders of leukocyte function.

Root RK.

Bull N Y Acad Med. 1982 Nov;58(8):669-80.

PMID: 6301588 Free PMC article. Review. No abstract available.

The role of antibody and complement in phagocytosis by rabbit alveolar macrophages.

Murphey SA, Root RK, Schreiber AD.

J Infect Dis. 1979 Dec;140(6):896-903. doi: 10.1093/infdis/140.6.896.

PMID: 120385

A randomized clinical trial of granulocyte transfusions for infection in acute leukemia.

Alavi JB, Root RK, Djerassi I, Evans AE, Gluckman SJ, MacGregor RR, Guerry D, Schreiber AD, Shaw JM, Koch P, Cooper RA.

N Engl J Med. 1977 Mar 31;296(13):706-11. doi: 10.1056/NEJM197703312961302.

PMID: 320477 Clinical Trial.

Role of myeloperoxidase in the respiratory burst of human neutrophils.

Nauseef WM, Metcalf JA, Root RK.

Blood. 1983 Mar;61(3):483-92.

PMID: 6297637 Free article.

Teaching compassion and respect. Attending physicians' responses to problematic behaviors.

Burack JH, Irby DM, Carline JD, Root RK, Larson EB.

J Gen Intern Med. 1999 Jan;14(1):49-55. doi: 10.1046/j.1525-1497.1999.00280.x.

PMID: 9893091 Free PMC article.

The microbicidal mechanisms of human neutrophils and eosinophils.

Root RK, Cohen MS.

Rev Infect Dis. 1981 May-Jun;3(3):565-98. doi: 10.1093/clinids/3.3.565.

PMID: 7025152 Review. No abstract available.

Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome.

Stossel TP, Root RK, Vaughan M.

N Engl J Med. 1972 Jan 20;286(3):120-3. doi: 10.1056/NEJM197201202860302.

PMID: 5007151 No abstract available.

Pathogenetic mechanisms in experimental immune fever.

Root RK, Wolff SM.

J Exp Med. 1968 Aug 1;128(2):309-23. doi: 10.1084/jem.128.2.309.

PMID: 4873023 Free PMC article.

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.

Nathan CF, Root RK.

J Exp Med. 1977 Dec 1;146(6):1648-62. doi: 10.1084/jem.146.6.1648.

PMID: 925614 Free PMC article.

Abnormal bactericidal, metabolic, and lysosomal functions of Chediak-Higashi Syndrome leukocytes.

Root RK, Rosenthal AS, Balestra DJ.

J Clin Invest. 1972 Mar;51(3):649-65. doi: 10.1172/JCI106854.

PMID: 4400956 Free PMC article.

Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects.

Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK.

Blood. 1986 Apr;67(4):1054-62.

PMID: 3006829 Free article.

Glucose-6-phosphate dehydrogenase deficiency and infection: a study of hospitalized patients in Iran.

Clark M, Root RK.

Yale J Biol Med. 1979 Mar-Apr;52(2):169-79.

PMID: 377826 Free PMC article. Clinical Trial.

Effects of oxygen exposure on it vitro function of pulmonary alveolar macrophages.

Murphey SA, Hyams JS, Fisher AB, Root RK.

J Clin Invest. 1975 Aug;56(2):503-11. doi: 10.1172/JCI108117.

PMID: 807601 Free PMC article.

Clinical problem-solving. Decision making by analogy.

Greenberg DL, Root RK.

N Engl J Med. 1995 Mar 2;332(9):592-6. doi: 10.1056/NEJM199503023320909.

PMID: 7838195 No abstract available.

Myeloperoxidase-mediated iodination by granulocytes. Intracellular site of operation and some regulating factors.

Root RK, Stossel TP.

J Clin Invest. 1974 May;53(5):1207-15. doi: 10.1172/JCI107667.

PMID: 4596505 Free PMC article.

Inhibition of zymosan activation of human neutrophil oxidative metabolism by a mouse monoclonal antibody.

Nauseef WM, Root RK, Newman SL, Malech HL.

Blood. 1983 Sep;62(3):635-44.

PMID: 6309281 Free article.

Bartonella (Rochalimaea) quintana bacteremia in inner-city patients with chronic alcoholism.

Spach DH, Kanter AS, Dougherty MJ, Larson AM, Coyle MB, Brenner DJ, Swaminathan B, Matar GM, Welch DF, Root RK, et al.

N Engl J Med. 1995 Feb 16;332(7):424-8. doi: 10.1056/NEJM199502163320703.

PMID: 7529895 Free article.

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

Root RK, Metcalf J, Oshino N, Chance B.

J Clin Invest. 1975 May;55(5):945-55. doi: 10.1172/JCI108024.

PMID: 1123431 Free PMC article.

Clinical use of granulocyte colony-stimulating factor in infectious diseases.

Gaviria JM, Garrido SM, Root RK.

Curr Clin Top Infect Dis. 2001;21:302-22.

PMID: 11572156 Review. No abstract available.

The etiology of community-acquired pneumonia at an urban public hospital: influence of human immunodeficiency virus infection and initial severity of illness.

Park DR, Sherbin VL, Goodman MS, Pacifico AD, Rubenfeld GD, Polissar NL, Root RK; Harborview CAP Study Group.

J Infect Dis. 2001 Aug 1;184(3):268-77. doi: 10.1086/322040. Epub 2001 Jun 26.

PMID: 11443551

Activation of complement by blood transfusion filters.

Snyder EL, Root RK, McLeod B, Dalmasso AP.

Vox Sang. 1983;45(4):288-93. doi: 10.1111/j.1423-0410.1983.tb01916.x.

PMID: 6636655

Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospital.

Goss CH, Rubenfeld GD, Park DR, Sherbin VL, Goodman MS, Root RK.

Chest. 2003 Dec;124(6):2148-55. doi: 10.1378/chest.124.6.2148.

PMID: 14665494

Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis.

Root RK, Lodato RF, Patrick W, Cade JF, Fotheringham N, Milwee S, Vincent JL, Torres A, Rello J, Nelson S; Pneumonia Sepsis Study Group.

Crit Care Med. 2003 Feb;31(2):367-73. doi: 10.1097/01.CCM.0000048629.32625.5D.

PMID: 12576938 Clinical Trial.

Salmonella septicemia from platelet transfusions. Study of an outbreak traced to a hematogenous carrier of Salmonella cholerae-suis.

Rhame FS, Root RK, MacLowry JD, Dadisman TA, Bennett JV.

Ann Intern Med. 1973 May;78(5):633-41. doi: 10.7326/0003-4819-78-5-633.

PMID: 4711769 No abstract available.

Granulocyte function in patients receiving lithium carbonate.

Cohen MS, Zahkireh B, Metcalf JA, Root RK.

Adv Exp Med Biol. 1980;127:335-46. doi: 10.1007/978-1-4757-0259-0_26.

PMID: 7405726 No abstract available.

Neutrophil function and host resistance.

Zakhireh B, Block LH, Root RK.

Infection. 1979;7(2):88-98. doi: 10.1007/BF01641619.

PMID: 35468

Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.

Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM.

J Immunol. 1987 Jan 15;138(2):513-9.

PMID: 2947951

Host defenses in the human neonate: ontogeny, role in protection against infection, possibilities for augmentation during sepsis.

Root RK.

Mead Johnson Symp Perinat Dev Med. 1982;(21):12-26.

PMID: 6085837 Review. No abstract available.

Paraquat suicide in a young woman: results of therapy directed against the superoxide radical.

Harley JB, Grinspan S, Root RK.

Yale J Biol Med. 1977 Sep-Oct;50(5):481-8.

PMID: 203128 Free PMC article.

Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.

Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, Buckley RH.

Am J Med. 1981 Jul;71(1):59-66. doi: 10.1016/0002-9343(81)90259-x.

PMID: 7195647

Possible nosocomial transmission of group Y Neisseria meningitidis among oncology patients.

Cohen MS, Steere AC, Baltimore R, von Graevenitz A, Pantelick E, Camp B, Root RK.

Ann Intern Med. 1979 Jul;91(1):7-12. doi: 10.7326/0003-4819-91-1-7.

PMID: 464460

Bactericidal and metabolic properties of human eosinophils.

Mickenberg ID, Root RK, Wolff SM.

Blood. 1972 Jan;39(1):67-80.

PMID: 4550469 Free article. No abstract available.

Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency.

Nauseef WM, Root RK, Malech HL.

J Clin Invest. 1983 May;71(5):1297-307. doi: 10.1172/jci110880.

PMID: 6189859 Free PMC article.

Impaired leukocyte function in patients with poorly controlled diabetes.

Bagdade JD, Root RK, Bulger RJ.

Diabetes. 1974 Jan;23(1):9-15. doi: 10.2337/diab.23.1.9.

PMID: 4809622 No abstract available.

Long-term survival after hospitalization for community-acquired and healthcare-associated pneumonia.

Cecere LM, Rubenfeld GD, Park DR, Root RK, Goss CH.

Respiration. 2010;79(2):128-36. doi: 10.1159/000255764. Epub 2009 Nov 4.

PMID: 19887771 Free PMC article.

Effect of microaggregate blood filtration on granulocyte concentrates in vitro.

Snyder EL, Root RK, Hezzey A, Metcalf J, Palermo G.

Transfusion. 1983 Jan-Feb;23(1):25-9. doi: 10.1046/j.1537-2995.1983.23183147299.x.

PMID: 6829054

Enhanced killing of penicillin-treated gram-positive cocci by human granulocytes: role of bacterial autolysins, catalase, and granulocyte oxidative pathways.

Isturiz R, Metcalf JA, Root RK.

Yale J Biol Med. 1985 Mar-Apr;58(2):133-43.

PMID: 4036175 Free PMC article.

Studies on the origin of human leukocytic pyrogen.

Nordlund JJ, Root RK, Wolff SM.

J Exp Med. 1970 Apr 1;131(4):727-43. doi: 10.1084/jem.131.4.727.

PMID: 5430786 Free PMC article.

Respiratory syncytial virus infections on an adult medical ward.

Takimoto CH, Cram DL, Root RK.

Arch Intern Med. 1991 Apr;151(4):706-8.

PMID: 2012452

H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: studies with normal and cytochalasin B-treated cells.

Root RK, Metcalf JA.

J Clin Invest. 1977 Dec;60(6):1266-79. doi: 10.1172/JCI108886.

PMID: 199619 Free PMC article.

Bactericidal and opsonic properties of C4-deficient guinea pig serum.

Root RK, Ellman L, Frank MM.

J Immunol. 1972 Sep;109(3):477-86.

PMID: 4403402 No abstract available.

Genetic disorders of leukocyte function: what they tell us about normal antimicrobial mechanisms of human phagocytic cells.

Root RK, Beeson PB.

Klin Wochenschr. 1982 Jul 15;60(14):731-4. doi: 10.1007/BF01716565.

PMID: 6289003

Unusually high occurrence of drug reactions with nafcillin.

Zakhireh B, Root RK.

Yale J Biol Med. 1978 Jul-Aug;51(4):449-55.

PMID: 155936 Free PMC article.

Comparison of interferon-gamma, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor for priming leukocyte-mediated hyphal damage of opportunistic fungal pathogens.

Gaviria JM, van Burik JA, Dale DC, Root RK, Liles WC.

J Infect Dis. 1999 Apr;179(4):1038-41. doi: 10.1086/314679.

PMID: 10068606

Enterococcal meningitis: combined vancomycin and rifampin therapy.

Ryan JL, Pachner A, Andriole VT, Root RK.

Am J Med. 1980 Mar;68(3):449-51. doi: 10.1016/0002-9343(80)90118-7.

PMID: 6892669

Structural analysis of human neutrophil migration. Centriole, microtubule, and microfilament orientation and function during chemotaxis.

Malech HL, Root RK, Gallin JI.

J Cell Biol. 1977 Dec;75(3):666-93. doi: 10.1083/jcb.75.3.666.

PMID: 562885 Free PMC article.

Preparation and function of 123I-labelled mononuclear phagocytes.

Goodhart GL, Root RK.

J Reticuloendothel Soc. 1979 Aug;26(2):115-20.

PMID: 490512 No abstract available.

Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. I. Demonstration of a defect in phagocytosis.

Drachman RH, Root RK, Wood WB Jr.

J Exp Med. 1966 Aug 1;124(2):227-40. doi: 10.1084/jem.124.2.227.

PMID: 4380670 Free PMC article.

Granulocyte collection by continuous-flow filtration leukapheresis.

Herzig GP, Root RK, Graw RG Jr.

Blood. 1972 Apr;39(4):554-67.

PMID: 4501526 Free article. No abstract available.

Granulocyte collection by continuous-flow filtration leukapheresis.

Herzig GP, Root RK, Graw RG Jr.

Blood. 1972 Apr;39(4):554-67.

PMID: 4501526 Free article. No abstract available.

Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia.

Miller SA, Bia FJ, Coleman DL, Lucia HL, Young KR Jr, Root RK.

Infect Immun. 1985 Jan;47(1):211-6. doi: 10.1128/iai.47.1.211-216.1985.

PMID: 2981196 Free PMC article.

D-Penicillamine: analysis of the mechanism of copper-catalyzed hydrogen peroxide generation.

Starkebaum G, Root RK.

J Immunol. 1985 May;134(5):3371-8.

PMID: 2984288

Genetic disorders of granulocyte function: what they tell us about normal mechanisms.

Root RK.

Adv Exp Med Biol. 1983;162:51-9. doi: 10.1007/978-1-4684-4481-0_5.

PMID: 6307016 No abstract available.

Enhancement of macrophage Fc-dependent phagocytosis by resident thymocytes: effect of a unique heat-stable lymphokine.

Coleman DL, Root RK, Ryan JL.

J Immunol. 1983 May;130(5):2195-9.

PMID: 6339624

Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections.

Clark RA, Root RK, Kimball HR, Kirkpatrick CH.

Ann Intern Med. 1973 Apr;78(4):515-9. doi: 10.7326/0003-4819-78-4-515.

PMID: 4571567 No abstract available.

Inhibition of human granulocyte function by methotrexate.

Hyams JS, Donaldson MH, Metcalf JA, Root RK.

Cancer Res. 1978 Mar;38(3):650-5.

PMID: 304760

Neutrophil response and function during acute cytomegalovirus infection in guinea pigs.

Yourtee EL, Bia FJ, Griffith BP, Root RK.

Infect Immun. 1982 Apr;36(1):11-6. doi: 10.1128/iai.36.1.11-16.1982.

PMID: 6281184 Free PMC article.

Interactions between antibiotics and human neutrophils in the killing of staphylococci.

Root RK, Isturiz R, Molavi A, Metcalf JA, Malech HL.

J Clin Invest. 1981 Jan;67(1):247-59. doi: 10.1172/JCI110020.

PMID: 7451652 Free PMC article.

Modulation of neutrophil-mediated activity against the pseudohyphal form of Candida albicans by granulocyte colony-stimulating factor (G-CSF) administered in vivo.

Gaviria JM, van Burik JA, Dale DC, Root RK, Liles WC.

J Infect Dis. 1999 May;179(5):1301-4. doi: 10.1086/314728.

PMID: 10191242 Clinical Trial.

Development of Oxidase activity by human bone marrow granulocytes.

Zakhireh B, Root RK.

Blood. 1979 Aug;54(2):429-39.

PMID: 454848 Free article. No abstract available.

The oxidative metabolism of thioglycollate-elicited mouse peritoneal macrophages: the relationship between oxygen, superoxide and hydrogen peroxide and the effect of monolayer formation.

Cohen MS, Ryan JL, Root RK.

J Immunol. 1981 Sep;127(3):1007-11.

PMID: 6267128

Granulocyte transfusion therapy: experimental basis and clinical applications.

Adler LM, Root RK.

J Am Osteopath Assoc. 1977 Apr;76(8):595-8.

PMID: 587713

The relationship of complement consumption to immune fever.

Mickenberg ID, Snyderman R, Root RK, Mergenhagen SE, Wolff SM.

J Immunol. 1971 Nov;107(5):1466-76.

PMID: 5117674 No abstract available.

The role of peroxidase in the bactericidal activity of human blood eosinophils.

Bujak JS, Root RK.

Blood. 1974 May;43(5):727-36.

PMID: 4132382 Free article. No abstract available.

Lectin-dependent neutrophil-mediated cytotoxicity against chicken erythrocytes: a model of non-myeloperoxidase-mediated oxygen-dependent killing by human neutrophils.

Greene WH, Colclough L, Anton A, Root RK.

J Immunol. 1980 Dec;125(6):2727-34.

PMID: 6253570 No abstract available.

Regulation of oxygen metabolism in human granulocytes: relationship between stimulus binding and oxidative response using plant lectins as probes.

Cohen MS, Metcalf JA, Root RK.

Blood. 1980 Jun;55(6):1003-10.

PMID: 7378576 Free article. No abstract available.

Indium-111-labeled human polymorphonuclear leukocytes: viability, random migration, chemotaxis, bacterial capacity, and ultrastructure.

Zakhireh B, Thakur ML, Malech HL, Cohen MS, Gottschalk A, Root RK.

J Nucl Med. 1979 Jul;20(7):741-7.

PMID: 120421 Free article.

Factors affecting the quantitative production and assay of human leukocytic pyrogen.

Root RK, Nordlund JJ, Wolff SM.

J Lab Clin Med. 1970 Apr;75(4):679-93.

PMID: 4910480 No abstract available.

Granulocyte function in patients with chronic renal failure: surface adherence, phagocytosis, and bactericidal activity in vitro.

Abrutyn E, Solomons NW, St Clair L, MacGregor RR, Root RK.

J Infect Dis. 1977 Jan;135(1):1-8. doi: 10.1093/infdis/135.1.1.

PMID: 833441

Skin reactivity of human subjects to a polysaccharide component of BCG culture filtrates.

Root RK, Wolff SM, Baer H.

Proc Soc Exp Biol Med. 1971 Feb;136(2):403-6. doi: 10.3181/00379727-136-35274.

PMID: 5544471 No abstract available.

Impaired response to pneumococcal vaccine in Hodgkin's disease.

Cadman E, Cohen MS, Root RK, Ryan JL, Minor DR.

N Engl J Med. 1978 Dec 7;299(23):1317-8. doi: 10.1056/NEJM197812072992322.

PMID: 30897 No abstract available.

Polymorphonuclear leukocytes prepared by continuous-flow filtration leukapheresis: viability and function.

Harris MB, Djerassi I, Schwartz E, Root RK.

Blood. 1974 Nov;44(5):707-13.

PMID: 4422170 Free article. No abstract available.

Immune fever in the rabbit: responses of the hematologic and complement systems.

Mickenberg ID, Snyderman R, Root RK, Mergenhagen SE, Wolff SM.

J Immunol. 1971 Nov;107(5):1457-65.

PMID: 5117673 No abstract available.

Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro.

Diamond RD, Root RK, Bennett JE.

J Infect Dis. 1972 Apr;125(4):367-76. doi: 10.1093/infdis/125.4.367.

PMID: 4553080 No abstract available.

The detection and characterization of phagocytic cells in established human cell lines synthesizing immunoglobulins.

Kammermeyer JK, Root RK, Stites DP, Glade PR, Chessin LN.

Proc Soc Exp Biol Med. 1968 Nov;129(2):522-7. doi: 10.3181/00379727-129-33360.

PMID: 4177061 No abstract available.

Successful treatment of rhinocerebral zygomycosis: a combined-strategy approach.

Gaviria JM, Grohskopf LA, Barnes R, Root RK.

Clin Infect Dis. 1999 Jan;28(1):160-1. doi: 10.1086/517193.

PMID: 10028102 No abstract available.