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Architect of Modern Medicine

Architect of Modern Medicine Architect of Modern Medicine Architect of Modern Medicine

Dr. Richard Kay Root

Dr. Richard Kay RootDr. Richard Kay Root

Dr. Richard Kay Root Publications.

  • Drachman RH, Root RK, and Wood WB, Jr.: Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. 1. Demonstration of a defect in phagocytosis. Journal of Experimental Medicine 124:227-240, 1966.
  • Wolff, SM, Kimball HR, Perry S, Root RK, and Kappas A: The biologic properties of etiocholanolone. Annals of Internal Medicine 67:1268-1295, 1967.
  • Root RK, and Wolff SM: Pathogenetic mechanisms in experimental immune fever. Journal of Experimental Medicine 128:309-323, 1968.
  • Kammermeyer JK, Root RK, Stites DP, Glade PR, and Chessin LN: The detection and characterization of phagocytic cells in established human cell lines synthesizing immunoglobulins. Proceedings of the Society of Experimental Biology and Medicine 129:522-527, 1968.
  • Root R , Nordlund JJ, and Wolff SM: Factors affecting the quantitative production and assay of human leukocytic pyrogen. Journal of Laboratory and Clinical Medicine 75:670-693, 1970.
  • Kordlund JJ,. Root RK, and Wolff SM: Studies on the origin of human leukocytic pyrogen. Journal of Experimental Medicine 131:727-743, 1970.
  • Mickenberg ID, Root RK, and Wolff SM: Leukocytic function in hypogammaglobulinemia. Journal of Clinical Investigation 49:1528-1538, 1970.
  • Root RK, Wolff SM, and Baer H: Skin reactivity of human subjects to a polysaccharide component of BCG culture filtrates. Proceedings of the Society of Experimental Biology and Medicine 136:4m--406, 1971.
  • Mickenberg lD, Synderman R, Root RK, Merganhagen SE, and Wolff SM: Immune fever in the rabbit: responses of the hematologic and complement systems. Journal of Immunology 107:1457- 1465, 1971.
  • Mickenberg ID, Synderman R, Root RK, Merganhagen SE, and Wolff SM: The relationship of complement consumption to immune fever. Journal of Immunology 107:1466-1476, 1971.
  • Mickenberg ID, Root RK, and Wolff SM: Bactericidal and metabolic properties of human eosinophils. Blood 39:67-80, 1972.
  • Wolff SM, Dale DC, Clark RA, Root RK, and Kimball HR: The Chediak-Higashi syndrome: studies of host defenses. Annals of Internal Medicine 76:293-306, 1972.
  • Stossel TP, Root RK, and Vaughn M: Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. New England Journal of Medicine 286:120-123, 1972.
  • Root RK, Rosenthal AS, and Balestra DJ: Abnormal bactericidal, metabolic, and lysosomal functions of Chediak-Higashi syndrome leukocytes. Journal of Clinical Investigation 51:649-665, 1972.
  • Diamond RD, Root RK, and Bennett JE: Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro. Journal of Infectious Diseases 125:367-376, 1972.
  • Herzig GP, Root RK., and Graw RG, Jr.: Granulocyte collection by continuous-flow filtration leukopheresis. Blood39:554-567, 1972.
  • Root RK, Ellman L, and Frank MD: Bactericidal and opsonic properties of C4-deficient guinea pig serum. Journal of Immunology 109:477-486, 1972.
  • Rudd FV, Root RK, Skoglund RW, Jr., and Ansel JS: Tumor-induced hypercalcemia. Journal of Urology l 07:986--989, 1972.
  • Rhame FS, Root RK, MacLowry JD, Dadisman TA, and Bennett JV: Salmonella cholera-suis septicemia outbreak caused by platelet transfusions from a hematogenous carrier. Annals of Internal Medicine 77:633-641, 1973.
  • Clark RA, Root RK, Kimball HR, and Kirkpatrick CH: Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections. Annals of Internal Medicine 78:515-519, 1973.
  • Bujak JS and Root RK: The role of peroxidase in the bactericidal activity of human blood eosinophils. Blood43:727, 1974.
  • Root RK and Stossel TP: Myeloperoxidase-mediated iodination by granulocytes: intracellular site of operation and some regulating factors. The Journal of Clinical Investigation 53:1207-1215, 1974.
  • Bagdade JD, Root RK, Bulger RJ: Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes 23:9-15, 1974.
  • Root RK, Harris MB, MacGregor RR, and Djerassi I: In vitro function of granulocytes collected by continuous-flow filtration leukopheresis. Proceedings of Leukocyte Transfusion Symposium, London, England, 1975.
  • Harris MB, Djerassi I, Schwartz E, and Root RK: Polymorphonuclear leukocytes prepared by continuous-flow filtration leukopheresis: viability and function. Blood 44:707, 1974.
  • Root RK, Metcalf J, Oshino N, and Chance B: H2O2release from human granulocytes during phagocytosis I. Documentation, quantitation, and some regulating factors. Journal of Clinical Investigation 55:945-955, 1975.
  • Murphy SA, Hyams JS, Fisher AB, and Root RK: Effects of oxygen exposure on in vitro function of pulmonary alveolar macrophages. Journal of Clinical Investigation 52:505-512, 1975.
  • Goodhart GL, Abrutyn E, Watson R, Root RK, and Egert J: Community-acquired Acinetobacter calcoaceTicus var anitratus pneumonia. JAMA 238:1516, 1977.
  • Harley JB, Grinspan S, and Root RK: Paraquat suicide in a young woman: results of therapy directed against the superoxide radical. The Yale Journal of Biology and Medicine 50:481-488, 1977.
  • Abrutyn E, Solomons NW, St. Clair L, MacGregor RR, and Root RK: Granulocyte function in patients with chronic renal failure: surface adherence, phagocytosis, and bactericidal activity in vitro. Journal of Infectious Disease135:18, 1977.
  • Alavi JB, Root RK, Djerassi I., et al: A randomized clinical trial of granulocyte transfusions for infection in acute leukemia. New England Journal of Medicine 296:706- 711, 1977.
  • Dvorak VD, Root RK, and MacGregor RR: Host-defense mechanisms in hidradenitis suppurative. Archives of Dermatology 113:450-453, 1977.
  • Root RK and Metcalf JA: H2O2 release from human granulocytes during phagocytosis: Relationship to superoxide anion formation and cellular catabolism of H2O2. Journal of Clinical Investigation 60:1266-1279, 1977.
  • Malech HL, Root RK, and Gallin JI: Structural analysis of human neutrophil migration: centriole, microtubule and microfilament orientation and function during chemotaxis. Journal of Cell Biology 75:666, l977.
  • Nathan CF and Root RK: Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. Journal of Experimental Medicine 146:1648- 1662, 1977.
  • Hyams JS, Donaldson MH, Metcalf JA, and Root RK: Inhibition of human granulocyte function by methotrexate. Cancer Research 38:650-655, 1978.
  • Zakhireh Band Root RK: Unusually high occurrence of drug reactions with nafcillin. Yale Journal of Biological Medicine 51:449-455, 1978.
  • Cadman E, Cohen MS, Root RK, Ryan JL and Minor DR: Impaired response to pneumococcal vaccine in Hodgkin's disease. New England Journal of Medicine 299:1317-1318, 1978.
  • Cohen MS, Steere AC, Baltimore R, Von Gravenitz A, Pantelick E, Camp B, and Root RK: Nosocomial transmission of group Y Neisseria meningitis among cancer patients. Annals of Internal Medicine 90:7, 1979.
  • Goodhart GL and Root RK: Preparation and function of 1125-labelled mononuclear phagocytes. Journal of Reticuloendothelial Society 26:115-120, 1979.
  • Clark M and Root: Glucose-6-phosphate dehydrogenase deficiency and infection: A study of hospitalized patients in Iran. Yale Journal of Biological Medicine 52:169-179, 1979.
  • Cohen MS, Zakhireh B, Metcalf JA, and Root RK: Granuloq,1e function during lithium therapy. Blood 53:913-915, 1979.
  • Zakhireh B, Thakur ML, Malech HL, Cohen MS, Gottshalk A, and Root RK: Viability, random migration, chemotaxis, bactericidal capacity and ultrastructure of indium-III labeled human polymorphonuclear leukocytes. Journal of Nuclear Medicine 20:741-747, 1979.
  • Zakhireh B and Root RK: Development of oxidase activity by human bone marrO\v granulocytes. Blood 54:429-439, 1979.
  • Murphey SA, Root RK, and Schreiber AD: The role of antibody and complement in phagocytosis by rabbit alveolar macrophages. Journal of Infectious Disease 140:986-993, 1979.
  • Cohen MS, Zakhireh B, Metcalf JA, and Root RK: Granulocyte function in patients receiving lithium carbonate: lithium effects on granulopoiesis and immune function. Advances in Experimental Medicine and Biology27:335-346, 1980.
  • Ryan JL, Pachner A, Andriole VT, Root RK. Annals of Internal Medicine 95:293-301, 1981.
  • Yourtee EL, Bia Fl, Griffith BT, and Root RK: Neutrophil response and function during acute cytomegalovirus infection in guinea pigs. Infection and Immunity 36:11-16, 1982.
  • Snyder EL, Root RK, Hezzey A, Metcalf JA, and Palermo G: Effect of microaggregate blood filtration on granulocyte concentrates in vitro. Transfusion 23:25-29, 1983.
  • NauseefWM,. Metcalf JA, and Root RK: Role of myeloperoxidase in the respiratory burst of human neutrophils. Blood 61:483-492, 1983.
  • Coleman DL, Root RK, and Ryan JL: Enhancement of macrophage Fe dependent phagocytosis by nonactivated thymocytes. J Immunol 130:2195-2199, 1983.
  • Nauseef RK, Root RK, and Malech HL: Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency. J Clin Invest 71:1297-1307, 1983.
  • Nauseef WM, Root RK, Newmann SL, and Malech HL: Inhibition of zymosan activation of human neutrophil oxidative metabolism by a mouse monoclonal antibody. Blood 62:635-644, 1983.
  • Snyder EL, Root RK, McLeod B, and Dalmasso AP: Activation of complement by blood transfusion filters. Vox Sang. 45:288-293, 1983.
  • Starkebaum G and Root RK: D-Penicillamine: analysis of the mechanisms of copper-catalyzed hydrogen peroxide generation. J Immunol 134:3371-3378, 1985.
  • Miller SA, Bia FJ, Coleman DL, Lucia HL, Young KR, and Root RK: Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia. Infection and Immunity 47:211-216, 1985.
  • Isturiz R, Metcalf JA, Root RK: Enhanced killing of penicillin-treated gram positive cocci by human granulocytes: Role of bacterial autolysins, catalase, and granulocyte oxidative pathways. Yale J Biol Med 58:133-143, 1985.
  • Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK: Monoclonal antibodies affecting the human neutrophil C3bi receptor. Blood 67:1054-1062, 1986.
  • Hickstein D, Smith A, Fisher W, Beatty P, Schwartz B, Harlan J, Root R, Locksley, R: Expression of leukoc:y te adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells. J. Immunol.138:513-519, 1987.
  • Takimoto CH, Cram DL, and Root RK: Respiratory Syncytial Virus Infectious on an Adult Medical Ward. Arch. Int. Med. 151:706-708, 1991.
  • Spach DH, Kanter, AS, Dougherty, MJ, Larson AM. Coyle MB, Brenner DJ, Swaminathan B, Matar GM, Welch DF, Root RK. Bartonella (Rochalimaea) Quintana Bacteremia in Inner-City Patients with Chronic Alcoholism. N Engl J Med 332:424-428, 1995.
  • Nelson, S, Belknap SM,Carlson, RW, Dale D, DeBoisblanc B, Farl<,as S, Fotheringham N, Ho H, Marrie T, Movahhed M, Root R, and John Wilson for the CAP Study Group. A Randomized Controlled Trial of Filgrastim as an Adjunct to Antibiotics for Treatment of Hospitalized Patients with Community-Acquired Pneumonia. JID178:10750-.1998.
  • JM Gaviria, SM Garrido, JH van Burik, DC Dale, RK Root. Impaired Neutrophil-Mediated Activity Against Aspergillus fumigatus. In patients following allogeneic hematopoietic stem cell transplantation: Restoration of function by Granulocyte Colony-Stimulating Factor (G-CSF), Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), or Interferon-y (IFN-y) in Vitro.
  • Gaviria JM. van Burik, JH, Dale DC, Liles CW, Root RK. Modulation ofNeutrophil-Medicated Activity Against the Pseudohyphal Form of Candida albicans by Granulocyte Colony-Stimulating Factor (G-CSF) JID 179:1301-4, 1999.
  • Gaviria JM, van Burik JH, Dale DC, and Root RK. Comparisons oflnterfem-y, Granulocyte Colony-Stimulating Factor, and Granulocy1e-y Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens. JID 179:1038-41, 1999.
  • Burack HI, Irby DM, Carline JD, Larson EB, and Root RK: Teaching Compassion and Respect. Attendings' Responses to Problematic Behavior. JGIM 14:49-55, 1999.
  • Root RK, Gaviria JM, Grohskopf LA, and Barnes R. Successful Treatment ofRhinocerebral Zygomycosis: A Combined Strategy Approach. Clin Infect Dis 28:160-161, 1999.
  • Nelson S, Heyder, AM, Stone J, Bergeron MG, Daugherty S, Peterson G, Fotheringham N, Welch W, Milwee S, Root R. A randomized controlled trial of filgrastim for the treatment of hospitalized patie

CV Publications

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