1959 Wesleyan University, B.A. Cum Laude (Biology) 1963 Johns Hopkins University, M.D. (Medicine)

1963-64

Intern in Medicine, Massachusetts General Hospital, Boston, MA.

1964-65

Assistant Resident in Medicine, Massachusetts General Hospital, Boston, MA.

1965-67

Clinical Associate, United States Public Health Service, Laboratory of Clinical Investigation,

National Institutes of Health, Bethesda, Maryland (Military Service)

1967-68

Clinical Investigator, Laboratory of Clinical Investigation, National Institute of Allergy and

Infectious Disease, National Institutes of Health, Bethesda, MD

1968-69

Chief Resident and Instructor, Department of Medicine, University Hospital, University of

Washington, Seattle, Washington

Facultv Appointments

1969-71 Senior Investigator, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD.

1971-73 Assistant Professor of Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

1973-75 Associate Professor of Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

1974 Visiting Associate Professor of Medicine, Pahlavi University School of Medicine., Shiraz, Iran (August-October)

1975-82 Professor of Medicine, Yale University School of Medicine, New Haven, CT.

I 982-85 Professor of Medicine, University of Washington School of Medicine, University of Washington, Seattle, WA.

1985-91 Professor of Medicine, University of California, San Francisco, CA.

1990 Visiting Professor of Medicine, Oxford University, Oxford, UK (April-July) 1991-2002 Professor of Medicine, University of Washington, Seattle, WA

1998 Visiting Professor of Medicine, University of Geneva, Geneva, Switzerland     (Feb-June) 

2002  Emeritus Professor of Medicine, University of Washington, Seattle WA

Hospital Positions Held

1971-75

Chief, Infectious Disease Section, Department of Medicine, University of Pennsylvania.

Philadelphia, Pennsylvania

1975-82

Chief, Infectious Disease Section, Department of Internal Medicine, Yale University School

of Medicine,. New Haven, Connecticut

1980-82

Vice Chairman, Dept. of Medicine, Yale University School of Medicine, New Haven, CT

1982-85

Chief, Medical Service, Seattle Veterans Administration Medical Center, Seattle, Washington

1982-85

Vice Chairman, Department of Medicine, University of Washington School of Medicine,

1985-89

University of Washington, Seattle. Washington

Physician-in--Chief, University of California, San Francisco Medical Center, San Francisco. CA

1985-89

Chairman, Department of Medicine, University of California, San Francisco, San Francisco, CA

1989-91

Associate Dean for Clinical Education. School of Medicine, University of California., San

Francisco, California

1991-2001 Chief, Medical Service, Harborview Medical Center, Seattle, Washington

1991-2001 Vice Chairman, Department of Medicine, University of Washington School of Medicine, Seattle, Washington

2001 -  Attending Physician, Division of Allergy and Infectious Disease Medical Science, Harborview Medical Center, Seattle, Washington

1959  Sigma Xi

1962-63  Dennison Scholar, Johns Hopkins University School of Medicine

1963  Phi Beta Kappa

1963-  Alpha Omega Alpha

1972-75   NCH Research Career Development (A170052) 1973  Master of Arts (Hon.) University of Pennsylvania

197

1975-2001  American Society for Clinical IAmerican Society for Clinical Investigation 

1975  Master of Arts (Hon.) Yale University

1977  Fellow, American College of Physicians (046011) 1979-200I Emeritus, Association of    American Physicians

1980-82  Paul B. Beeson Professor of Medicine, Yale University School of Medicine

1982  Medical Housestaff Teacher of the Year Award. Yale University School of Medicine

1969- Diplomate, American Board of Internal Medicine (No. 31852)

1966-2002  American Federation for Clinical Research Councilor, Eastern Section, 1976- 78 President, Eastern Section, 1978-79

1969 Fellow, Infectious Diseases Society of America 1979-2002 American Society for    Hematology

1979-  Fellow American College of Physicians 1980-2002 Association of American    Immunologists 

1980 American Society of Microbilogy

1980-85 ICAAC Program Committee

1981-82 Board of Trustees, Hospice of Connecticut, Branford, CT.

1981-82  Board of Trustees, Yale-China Association, Yale University School of Medicine 1983   Western Association of Physicians

Councilor, 1987-89

President-elect, 1996-97

President, 1997-98

Past President, 1998-99

1984-89 American Board of Internal Medicine, Infectious Disease Subcommittee

1985-97 Association of Professors of Medicine

1988-93 AE1erican Clinical and Climatological Association 1993-2002 Society for General Internal Medicine

l 996 - The Infectious Diseases Society of Washington 2000-  Seattle Academv of Internal Medicine. Seattle. WA 2000-  Physicians for Social Responsibility

1974-84

Antimicrobial Agents and Chemotherapy

1978-79

Infectious Disease Board, Medical Knowledge Self-Assessment Program V (MKSAP VJ,

American College of Physicians

1982-92

Medicine

1990-93

Annals of Internal Medicine

1991-92

Advisor The Internal Medicine Resident (Bi-monthly journal)

1992-95

The American Journal of Medicine

1992-94

Section Editor, Infectious Diseases Subcommittee, Medical Knowledge Self-Assessment

Program X (MKSAP X), American College of Physicians

1993-

Scientific Therapeutics Information, Inc.: The Neutrophil: Importance in Host Defense

(Monograph series).

Contemporaff Issues in Infectious Diseases Churchill-Livingstone, New York

1984

Vol.

I.

New Dimensions in Antimicrobial Therapy

RK Root, MA Sande, Eds.

1984

Vol.

2.

Endocarditis

1985

Vol.

  3..

MA Sande, D Kaye, RK Root. Eds. 

Bacterial Meningitis

MA Sande, AL Smith, RK Root, Eds.

1985

Vol.

4.

Septic Shock

RK Root, MA Sande, Eds.

1985

Vol.

5.

Respiratory Infections

MA Sande, L. Hudson, RK Root Eds.

1987

Vol.

6.

New Surgical and Medical Approaches

RK Root, D. Trunkey, MA Sande, Eds.

1987

Vol.

7.

Parasitic Infections

MA Sande, J. Leech, RK Root, Eds.

1987

Veil.

8.

Immunization

RK Root, K. Warren, JM Griffiss, MA Sande, Eds.

1992

Vn.

9.

Treatment of Serious Infections in the 1990s

MA Sande, RK Root, Eds.

1993

Vol

10.

Viral Infections

MA Sande, RK Root, Eds.

Western Journal of Medicine

1987 Epitome Series, (Ed.) RK Root

Harrison's Principles oflnternal Medicine. McGraw-Hill, Ne,v York, 1990, 12th Edition. (Eds.) Braunwald E, lsselbacher KJ, Petersdorf, RG., Wilson JD, Martin JB, Fauci AS, and Root RK.

Harrison's Principles of Internal Medicine. Companion Handbook. Mc-Graw-hill, New York, 1991, 12th Edition. (Eels.) Braunwald E., Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS, and Root RK.

Clinical Infectious Diseases: A Practical Approach. Oxford University Press, New York, 1999. 1st Edition, Root RK, (Editor-in-Chief), (Eds) Waldvogel F, Corey L, and Stamm WE.

Special National Responsibilities

1976-78

Ad hoc Study Section, National Institutes of Allergy and Infectious Diseases. National

Institutes of Health, Bethesda, Maryland

1978-79

Bacteriology and Mycology Study Section (AHR), National Institute of Health

1979-81

Microbiology Study Section, National Institutes of Health

1985-87

Scientific Subcommittee on Leukocyte Physiology, American Society Hematology

1986-88

NIAID Director AIDS Advisory Committee

1986-91

Member, University wide Task Force on AIDS, University of California, chair, 1990-91

1987-89

NIAAID/NIH Advisory Committee on AIDS

1991

Ad Hoc Committee on Housestaff Participation, Association of American Medical Colleges,

Washington, D.C.

1994 -96

In-Trainings Examination Committee, American College of Physicians

Special Lo•:al Responsibilities:

University of Pennsylvania School of Medicine, 1971-75

1971-75

Attending Physician, Hospital of the University of Pennsylvania, Philadelphia, PA

1971-75

Consulting Physician, VAMC, Philadelphia, PA

1971-75

Consulting Physician, Philadelphia General Hospital, Philadelphia, PA

1971-75

Chairman, Infections Committee, Hospital of the University of Pennsylvania, Philadelphia, PA

1971-75

Member, Pharmacy and Therapeutics Committee, Hospital of the University of Pennsylvania,

Philadelphia, PA

1972-75

Member, Executive Committee, Department of Medicine, University of Pennsylvania,

Philadelphia, PA

1972-75

Member, Internship Selection Committee, Department of Medicine, University of

Pennsylvania School of Medicine, Philadelphia, PA

1973-75

Member, Medical Board, Hospital of the University of Pennsylvania, Philadelphia, PA

1973-75

Member, Professional Staff Committee, Hospital of the University of Pennsylvania, Philadelphia, PA

Yale Univt 1rsity School of Medicine, 1975-82

1975-82

Attending Physician, Yale-New Haven Hospital, New Haven, CT

1975-82

Consulting Physician, VAMC, West Haven, CT

1975-82

Member, Executive Committee, Department of Internal Medicine, Yale University School of

Medicine, New Haven, CT

1975-81

Member, Appointments and Promotions Committee, Department of Internal

Medicine, Yale University School of Medicine, New Haven, CT

1976-77

Chairman, In-Patient Planning Committee, Department of Internal Medicine, Yale

University School of Medicine, New Haven, CT

1977-80

Member, Infections Committee, Yale-New Haven Hospital, New Haven, CT

1977-80

Member, Committee on the Status of Women, Yale University School of Medicine, New

Haven, CT

1977-82

Member, Clinical Education Committee, Department of Internal Medicine, Yale

University School of Medicine, New Haven, CT

1978-81

Meember, Planning and Priorities Committee, Yale University School of Medicine,

New Haven, CT

1979-82

Member, Medical Committee, Yale-China Association, Yale University School of

\1edicine, New Haven, CT

1980-82

Chairman, In-Patient Planning Committee, Department of Internal Medicine, Yale

University School of Medicine, New Haven, CT

1980-82

Chainnan, Space Committee, Department of lnternal Medicine, Yale University

School of Medicine, New Haven, CT

1980-82

Member, Internship Selection Committee, Department of Internal Medicine, Yale

University School of Medicine, New Haven, CT

1980-81

Member, Task Force on Governance, Yale-New Haven Hospital, New Haven, CT

1980-82

Vice--Chainnan, Department of Internal Medicine, Yale University School of

Medicine, New Haven, CT

1980-82

Assistant Chief of Medicine, Yale-New Haven Hospital, New Haven, CT

1981-82

Acting Chairman, Department of Internal Medicine, Yale University School of

Medicine, New Haven, CT

1981-82

Acting Chief of Medicine, Yale-New HaYen Hospital, New Haven, CT

1981-82

Member, Medical Board, Yale-New Haven Hospital, New Haven, CT

1981-82

Member, Executive Committee, Yale-New Haven Hospital, New Haven, CT

1981-82

Member, Executive Committee, Faculty Practice Plan, Yale University School of

Medicine, New Haven, CT

Universitv of \Vashington, 1982-85

1982-85 Member, Steering Committee, Department of Medicine, University of Washington, Seattle, WA 1982-85 Member, Internal Medicine Residency Selection Committee, Department of Medicine,

University of Washington, Seattle, WA

I 983-85 Member, Appointments and Promotions Committee (Associate Professors), Department of Medicine, University of Washington, School of Medicine, Seattle,WA

1983-85 Chairman (1984), Appointments and Promotions Committee (Professors) Department of Medicine,University of Washington School of Medicine, Seattle, WA

1984-85 Member, University of Washington Affiliated Hospital Network Medical Directors, University of Washington School of Medicine, Seattle, WA

1984-85  Member, Department of Psychiatry Chairman Search Cm., University of Washington School of Medicine, Seattle, WA

1982-85

Member, Clinical Executive Board, Veterans Administration Medical Ctr, Seattle, WA

1982-85

\Ifember, Research and Development Cm., Veterans Administration Medical Ctrr, Seattle, WA

1982-85

Member, Position Management Committee, Veterans Administration Medical Ctr, Seattle, WA

1982-85

\lfember, Professional Standards Board, Veterans Administration Medical Center, Seattle, WA

1982-85

Chairman, Female Veterans Health Care Cm., Veterans Administration Medical Ctr, Seattle, WA

1982-83

Ifember, Chief of Hematology Search Corrunittee, Veterans Administration Medical Ctr,

1982-83

Seattle, WA

\1ember, Chief of Dermatology Search Cm., Veterans Administration Medical Center,

1983-84

Seattle, WA

Chairman, Chief of Staff Search Cm., Veterans Administration Medical Center, Seattle, WA

1983-84

Chairman, Chief of Gerontology Search Cm., Veterans Administration Medical Ctr, Seattle, WA

1983-84

),1ember, Chief of Neurology Search Cm., Veterans Administration Medical Ctr, Seattle, WA

University of California, San Francisco, 1985-91

1985-86

Member, Committee on Patient Care, University of California, San Francisco, San Francisco, CA

1985-86

Member, Dean's AIDS Advisory Committee, University of California, San Francisco,

San Francisco, CA

1985-87

\1ember, Surgery Chairman Search Cm, University of California, San Francisco, S. Fran., CA

1985-89

Chief: Medical Service, Moffitt/Long Hospitals, University of California, San Francisco,

San Francisco, CA

1985-89

)\rfember, Joint Planning Committee, UCSF/Mt. Zion Medical Center, University of

California, San Francisco, San Francisco, CA

1985-89

]Vlember, Committee on Research of the Academic Senate, University of California,

San Francisco, San Francisco, CA

1985-89

Member, Dean's Advisory Cm, University of California, San Francisco, San Francisco, CA

1985-89

Member, Dean's Executive Cm, University of California, San Francisco, San Francisco, CA

1985-89

Member, Professional Services Steering Committee, University of California, San Francisco,

San Francisco, CA

1985-89

Member, Society of Professional Association Nomination Committee, University of

California, San Francisco, San Francisco, CA

1985-90

Member, Residency Selection Committee, Department of Medicine, University of California,

1985-

San Francisco, San Francisco, CA

Member, Governing Board of Continuing Medical Education, University of California San

Francisco, San Francisco, CA

1985-91

Member, Cm. on Educational Policy, University of California, San Francisco, S. Fran., CA

1986-87

i\1[ember, Pediatric Chairman Search Cm, University of California, San Francisco,

San Francisco, CA

1986-87

!\![ember, Ad Hoc Peer Review, University of California, San Francisco, San Francisco, CA

1987-89

Dean's Committee to Review New and Existing Programs, University of California,

San Francisco, San Francisco, CA

1987-89

  Member, Executive Cm, Clinical Practice Organization, University of California, S. Fran., CA

1987-89

Chairman, Cardiac Catheterization Laboratory Utilization Review Committee, Department of

Medicine, University of California, San Francisco, San Francisco, CA

1987-89

Member, Howard Hughes Medical Institute Committee. University of California,

San Francisco, San Francisco, CA

1988-89

Chairman, Universitywide Task Force on AIDS, University of California Systemwide

1988-89

Member, Dean's Search Committee, University of California San Francisco. San Fran., CA

1988-91

Member, Chancellor's AIDS Coordinating Council, University of California San Francisco,

San Francisco, CA

1988-91

Member, William K. Hamilton Visiting Lectureship Committee, University of California.

San Francisco, San Francisco, CA

1989-91

Member, Chancellor's Distinguished Lectureship Committee, University of California, San

Francisco, San Francisco, CA

1989-90

Member, UCSF/Mt. Zion Clinical Planning Committee, University of California San

Francisco, San Francisco, CA

1989-90

Chaimian, Ad HocGrading Policies Cm., University of California San Francisco, S. Fran., CA

1989-90

M, mber, Curriculum Committee, University of California San Francisco, S. Fran., CA

1989-90

Chairman, Subcommittee for Ambulatory Care Longitudinal Clinic, University of

California San Francisco, San Francisco, CA

1989-90

1989-90

Chairman, Search Committee for Associate Director of PulmonaryNice Chairman, Department of Medicine, Department of Medicine, University of California San Francisco,

San Francisco, CA

Member, 1990 International AIDS Conference Program and Planning Committee,

University of California San Francisco, San Francisco, CA

1989-91

Chairman, Post Doctoral Advisory Committee, University of California, San Francisco,

San Francisco, CA

1989-91

Member, Ad Hoc Faculty Review Committee, University of California San Francisco,

San Francisco., CA

1989-91

Member, Undergraduate Medical Education Cm., University of California San Francisco, San

Francisco, CA

1990-91

Member, Biosafety Committee, School of Medicine, University of California, San Francisco.

San Francisco, CA,

1990-91

Member, Physicians' Well Being Committee, University of California, San Francisco,

San Francisco, CA

1990-91

Promotions Committee, University of California, San Francisco, San Francisco, CA

1990-91

Member, University of California, Berkeley/University of California, San Francisco Joint

Medical Program Committee, University of California, San Francisco, San Francisco, CA

1990-91

Chief. Department of Medicine Firm System for In-Patient Care, University of California,

San Francisco, San Francisco, CA

University of Washington, Seattle, Washington, 1991-

1991 -

Attending Physician, University of Washington Medical Center

Harborview Medical Center, Seattle, WA

1991 -

Member, Distinguished Society Committee, Department of Medicine, University of

Washington School of Medicine, Seattle, WA

1991-

Member, Clinical Competence Committee, Department of Medicine, University of

Washington School of Medicine, Seattle, WA

1991 -

Member, Intern Selection Committee (Traditional Program), Department of Medicine,

University of Washington School of Medicine, Seattle, WA

1992-97

Member, Committee to Review Disability Insurance Options for Housestaff, University of

Washington School of Medicine, Seattle, WA

1992

Chairman, Residency Advisory Committee, Department of Medicine, University of

Washington School of Medicine, Seattle, WA

1992-93

Member, Appointments and Promotions Committee, Department of Medicine, University of

vv·ashington, Seattle, WA

1992-93

Chairman, Medicine/Psychiatry Residency Training Program Committee, Dearptment of

Medicine, University of Washington, Seattle, WA

1992-95

Chairman, Head of General Internal Medicine Division Search Committee, Department of

Medicine, University of Washington, Seattle, WA

1992-95

Member, Dean's Council on Scientific Affairs, School of Medicine, University of

Washington, Seattle, WA

1993

Member, Professors' Review Committee, Department of Medicine, University of

Washington, Seattle. WA

1994

Member, Cardiothoracic/Cardiology Long Range Planning Committee, Department of

Medicine, University of Washington, Seattle, WA

1995

Member, Ad Hoc Committee for Recommendations Regarding Size and Primary Location for

Residency Training Program, Department of Medicine, Univ of Washington, Seattle,

WA

1996-98

Member, Dean's Council on Academic Affairs, School of Medicine, University of Washington, Seattle, WA

1999-

Member, Steering Committee, Health Science Partnerships in Clinical Education (HSPICE)

1991

Member, Joint Harborview Medical Center/University of Washington Medical Center AIDS

Clinical Task Force, University of Washington School of Medicine, Seattle, WA

1991

Member, Ad Hoc Cm. for Harbon:iew Medical Center Goverance, Harborview Medical

Center, Seattle, WA

1991

Member, .Ambulatory Care Center Coordinating Cm., Harborview Medical Center, Seattle, WA

1991

Member, Search Committee, Chief, Cardiology, Harborview Medical Center, Seattle, WA

1991

Member, Finance Committee, Harborvie\v Medical Center, Seattle, WA

1991

Member, Long Range Capital Improvement Project, Harborvie\V Medical Center, Seattle, WA

1991

Member, Medical Executive Board, Harborvie\\· Medical Center, Seattle, WA

1991-95

Member, Quality Assurance Committee, Harborview Medical Center, Seattle, WA

1991

Member, Review Committee for STD-HIV Strategic Planning At Harborview Medical

Center, Seattle, WA

1992

Member, Joint University of Washington School of Medicine/Harborview Medical Center

1992

Chairman, Search Committee, Chief, Radiology Service, Harborview Medical Center, School

of Medicine, University of Washington, Seattle, WA

1992

Chairman, Search Committee, Associate Administrator for Patient Care Services Search

Committee, Harborview Medical Center, Seattle, WA

1995

Member, Search Committee, Chief Family Medicine, Harborview Medical Center, Seattle,

WA

1999-2000 Acting Chief, Section of General Internal Medicine, Harborview Medical Center, Seattle, WA 2001 Chair, Safety Net Task Force, Harborview Medical Center

Host defense mechanisms in infection Human phagocytic cell function

Pathogenesis and management of sepsis and septic shock

Epidemiology, management and outcomes of community acquired pneumonia Use of colony-Stimulating factors in the treatment of infectious diseases

April 1983

October 1985-

May 1986

October 1986

April 1987

October 1987

Brainerd Visiting Professorship, University of California, San Francisco, S. Fran., CA George W. Thom Visiting Professorship, Brigham and Women's Hospital, Harvard University, Boston, MA

Paul B. Beeson Visiting Professorship, Yale University, New Haven, CT Bowman Visiting Professorship, University of Virginia, Charlottesville, VA WiHiam J. Harrington Visiting Professorship, University of Miami, Miami, FL Cyris Sturgis Visiting Professorship, University of Michigan, Ann Arbor, MI

January 1988

December 1988

March 1989

May 1996

March 2000

John S. Lawrence Visiting Professorship, UCLA, University of California, Los Angeles, Los Angeles, CA

Hm:vard Hiatt Visiting Professor, Harvard Medical School, Boston, MA University of New South Wales Visiting Professorship, University ofNevv South Wales, Sydney, Australia

Philip Bondy Visiting Professorship, Yale University Sch. Med., New Haven, CT

John A. Bums School of Medicine/Queens Hospital Visiting Professor

1. Peer-Reviewed Publications
2. Drachman RH, Root RK, and Wood WB, Jr.: Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. 1. Demonstration of a defect in phagocytosis. Journal of Experimental Medicine 124:227-240, 1966.
3. Wolff, SM, Kimball HR, Perry S, Root RK, and Kappas A: The biologic properties of etiocholanolone. Annals of Internal Medicine 67:1268-1295, 1967.
4. Root RK, and Wolff SM: Pathogenetic mechanisms in experimental immune fever. Journal of Experimental Medicine 128:309-323, 1968.
5. Kammermeyer JK, Root RK, Stites DP, Glade PR, and Chessin LN: The detection and characterization of phagocytic cells in established human cell lines synthesizing immunoglobulins. Proceedings of the Society of Experimental Biology and Medicine 129:522-527, 1968.
6. Root R , Nordlund JJ, and Wolff SM: Factors affecting the quantitative production and assay of human leukocytic pyrogen. Journal of Laboratory and Clinical Medicine 75:670-693, 1970.
7. Kordlund JJ,. Root RK, and Wolff SM: Studies on the origin of human leukocytic pyrogen. Journal of Experimental Medicine 131:727-743, 1970.
8. Mickenberg ID, Root RK, and Wolff SM: Leukoc11ic function in hypogammaglobulinemia. Journal of Clinical Investigation 49:1528-1538, 1970.
9. Root RK, Wolff SM, and Baer H: Skin reactivity of human subjects to a polysaccharide component of BCG culture filtrates. Proceedings of the Society of Experimental Biology and Medicine

136:4m--406, 1971.

1. Mickenberg lD, Synderman R, Root RK, Merganhagen SE, and Wolff SM: Immune fever in the rabbit: responses of the hematologic and complement systems. Journal of Immunology 107:1457- 1465, 1971.
2. Mickenberg ID, Synderman R, Root RK, Merganhagen SE, and Wolff SM: The relationship of complement consumption to immune fever. Journal of Immunology 107:1466-1476, 1971.
3. Mickenberg ID, Root RK, and Wolff SM: Bactericidal and metabolic properties of human eosinophils. Blood 39:67-80, 1972
4. Wolff SM, Dale DC, Clark RA, Root RK, and Kimball HR: The Chediak-Higashi syndrome: studies of host defenses. Annals of Internal Medicine 76:293-306, 1972
5. Stossel TP, Root RK, and Vaughn M: Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. New England Journal of Medicine 286:120-123, 1972
   
6. *Root RK, Rosenthal AS, and Balestra DJ: Abnormal bactericidal, metabolic, and lysosomal functions of Chediak-Higashi syndrome leukocytes. Journal of Clinical Investigation 51:649-665, 1972.
7. Diamond RD, Root RK, and Bennett JE: Factors influencing killing of Cryptococcus neoformans by human leukocytes in vitro. Journal of Infectious Diseases 125:367-376, 1972.
8. Herzig GP, Root RK., and Graw RG, Jr.: Granulocyte collection by continuous-flow filtration leukopheresis. Blood 39:554-567, 1972.
9. Root RK, Ellman L, and Frank MD: Bactericidal and opsonic properties of C4-deficient guinea pig serum. Journal of Immunology 109:477-486, 1972.
10. Rudd FV, Root RK, Skoglund RW, Jr., and Ansel JS: Tumor-induced hypercalcemia. Journal of Urology l 07:986--989, 1972.
11. Rhame FS, Root RK, MacLowry JD, Dadisman TA, and Bennett JV: Salmonella cholera-suis septicemia outbreak caused by platelet transfusions from a hematogenous carrier. Annals of Internal Medicine 77:633-641, 1973.
12. Clark RA, Root RK, Kimball HR, and Kirkpatrick CH: Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections. Annals of Internal Medicine 78:515-519, 1973.
13. Bujak JS and Root RK: The role of peroxidase in the bactericidal activity of human blood eosinophils. Blood 43:727, 1974.
14. *Root RK and Stossel TP: Myeloperoxidase-mediated iodination by granulocytes: intracellular site of operation and some regulating factors. The Journal of Clinical Investigation 53:1207-1215, 1974.
15. Bagdade JD, Root RK, Bulger RJ: Impaired leukocyte function in patients with poorly controlled diabetes. Diabetes 23:9-15, 1974.
16. Root RK, Harris MB, MacGregor RR, and Djerassi I: In vitro function of granulocytes collected by continuous-flow filtration leukopheresis. Proceedings of Leukocyte Transfusion Symposium, London, England, 1975.
17. Harris MB, Djerassi I, Schwartz E, and Root RK: Polymorphonuclear leukocytes prepared by continuous-flow filtration leukopheresis: viability and function. Blood 44:707, 1974.
18. *Root RK, Metcalf J, Oshino N, and Chance B: H2O2release from human granulocytes during

phagocytosis I. Documentation, quantitation, and some regulating factors. Journal of Clinical Investigation 55:945-955, 1975.

].7_ Murphy SA, Hyams JS, Fisher AB, and Root RK: Effects of oxygen exposure on in vitro function of pulmonary alveolar macrophages. Journal of Clinical Investigation 52:505-512, 1975.

1. Goodhart GL, Abrutyn E, Watson R, Root RK, and Egert J: Community-acquired Acinetobacter calcoaceTicus var anitratus pneumonia. JAMA 238:1516, 1977.
2. Harley JB, Grinspan S, and Root RK: Paraquat suicide in a young woman: results of therapy directed against the superoxide radical. The Yale Journal of Biology and Medicine 50:481-488, 1977.
3. Abrutyn E, Solomons NW, St. Clair L, MacGregor RR, and Root RK: Granulocyte function in patients with chronic renal failure: surface adherence, phagocytosis, and bactericidal activity in vitro. Journal of Infectious Disease 135:18, 1977.
4. Alavi JB, Root RK, Djerassi I., et al: A randomized clinical trial of granulocyte transfusions for infection in acute leukemia. Nev, England Journal of Medicine 296:706- 711, 1977.
5. Dvorak VD, Root RK, and MacGregor RR: Host-defense mechanisms in hidradenitis suppurative. Archives of Dermatology 113:450-453, 1977.
6. *Root RK and Metcalf JA: H2O2 release from human granulocytes during phagocytosis: Relationship to superoxide anion formation and cellular catabolism of H2O2. Journal of Clinical Investigation 60:1266-1279, 1977.
7. Malech HL, Root RK, and Gallin JI: Structural analysis of human neutrophil migration: centriole, microtubule and microfilament orientation and function during chemotaxis. Journal of Cell Biology 75:666, l977.
8. Nathan CF and Root RK: Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. Journal of Experimental Medicine 146:1648- 1662, 1977.
9. Hyams JS, Donaldson MH, Metcalf JA, and Root RK: Inhibition of human granulocyte function by methotrexate. Cancer Research 38:650-655, 1978.
10. Zakhireh Band Root RK: Unusually high occurrence of drug reactions with nafcillin. Yale Journal of Biological Medicine 51:449-455, 1978.
11. Cadman E, Cohen MS, Root RK, Ryan JL and Minor DR: Impaired response to pneumococcal vaccine in Hodgkin's disease. Nev,.: England Journal of Medicine 299:1317-1318, 1978.
12. Cohen MS, Steere AC, Baltimore R, Von Gravenitz A, Pantelick E, Camp B, and Root RK: Nosocomial transmission of group Y Neisseria meningitis among cancer patients. Annals of Internal Medicine 90:7, 1979.

40. Goodhart GL and Root RK: Preparation and function of 1125-labelled mononuclear phagocytes. Journal ofReticuloendothelial Society 26:115-120, 1979.

Clark M and Root: Glucose-6-phosphate dehydrogenase deficiency and infection: A study of hospitalized patients in Iran. Yale Journal of Biological Medicine 52:169-179, 1979.

Cohen MS, Zakhireh B, Metcalf JA, and Root RK: Granuloq,1e function during lithium therapy. Blood 53:913-915, 1979.

Zakhireh B, Thakur ML, Malech HL, Cohen MS, Gottshalk A, and Root RK: Viability, random migration, chemotaxis, bactericidal capacity and ultrastructure of indium-III labeled human polymorphonuclear leukocytes. Journal ofNuclear Medicine 20:741-747, 1979.

Zakhireh B and Root RK: Development of oxidase activity by human bone marrO\v granulocytes. Blood 54:429-439, 1979.

Murphey SA, Root RK, and Schreiber AD: The role of antibody and complement in phagocytosis by rabbitt alveolar macrophages. Journal of Infectious Disease 140:986-993, 1979.

Cohen MS, Zakhireh B, Metcalf JA, and Root RK: Granulocyte function in patients receiving lithium carbonate: lithium effects on granulopoiesis and immune function. Advances in Experimi:ntal Medicine and Biology 27:335-346, 1980.

Ryan JL, Pachner A, Andriole VT, Root RK. Annals of Internal Medicine 95:293-301, 1981.

Yourtee EL, Bia Fl, Griffith BT, and Root RK: :'.'Neutrophil response and function during acute cytomegalovirus infection in guinea pigs. Infection and Immunity 36:11-16, 1982.

Snyder EL, Root RK, Hezzey A, Metcalf JA, and Palermo G: Effect of microaggregate blood

filtration on granulocyte concentrates in vitro. Transfusion 23:25-29, 1983.

NauseefWM,. Metcalf JA, and Root RK: Role of myeloperoxidase in the respiratory burst of human

neutrophils. Blood 61:483-492, 1983.

Coleman DL, Root RK, and Ryan JL: Enhancement of macrophage Fe dependent phagocytosis by nonactivated thymocytes. J Immunol 130:2195-2199, 1983.

Nauseef RK, Root RK, and Malech HL: Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency. J Clinlnvest 71:1297-1307, 1983.

Nauseef W:\1, Root RK, Newmann SL, and Malech HL: Inhibition of zymosan activation of human neutrophil oxidative metabolism by a mouse monoclonal antibody. Blood 62:635-644, 1983.

Snyder EL, Root RK, McLeod B, and Dalmasso AP: Activation of complement by blood transfusion filters. Vox Sang. 45:288-293, 1983.

Starkebaum G and Root RK: D-Penicillamine: analysis of the mechanisms of copper-catalyzed hydrogen peroxide generation. J Immunol 134:3371-3378, 1985.

Miller SA, Bia FJ, Coleman DL, Lucia HL, Young KR, and Root RK: Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia. Infection and Immunity 47:211-216, 1985.

Isturiz R, MetcalfJA, Root RK: Enhanced killing of penicillin-treated gram positive cocci by human granulocytes: Role of bacterial autolysins, catalase, and granulocyte oxidative pathways. Yale J Biol Med 58:133-143, 1985.

Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK: Monoclonal antibodies affecting the human neutrophil C3bi receptor. Blood 67:1054-1062, 1986.

Hickstein D, Smith A, Fisher W, Beatty P, Schwartz B, Harlan J, Root R, Locksley, R: Expression of leukoc:y te adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.. J. Immunol. 138:513-519, 1987.

Takimoto CH, Cram DL, and Root RK: Respiratory Syncytial Virus Infectious on an Adult Medical Ward. Arch. Int. Med. 151:706-708, 1991.

Spach DH, Kanter, AS, Dougherty, MJ, Larson AM. Coyle MB, Brenner DJ, Swaminathan B, Matar GM, Welch DF, Root RK. Bartonella (Rochalimaea) Quintana Bacteremia in Inner-City Patients with Chronic Alcoholism. N Engl J Med 332:424-428, 1995

Nelson, S, Belknap SM,Carlson, RW, Dale D, DeBoisblanc B, Farl<,as S, Fotheringham N, Ho H, Marrie T, Movahhed M, Root R, and John Wilson for the CAP Study Group. A Randomized Controlled Trial of Filgrastim as an Adjunct to Antibiotics for Treatment of Hospitalized Patients with Community-Acquired Pneumonia. JID 178:10750-.1998.

JM Gavina, SM Garrido, JH van Burik, DC Dale, RK Root. Impaired Neutrophil-Mediated Activity Against Aspergillus fumigatus. In patients following allogeneic hematopoietic stem cell transplantation: Restoration of function by Granulocyte Colony-Stimulating Factor (G-CSF), Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), or Interferon-y (IFN-y) in Vitro.

Gaviria JM. van Burik, JH, Dale DC, Liles CW, Root RK. Modulation ofNeutrophil-Medicated Activity Against the Pseudohyphal Form of Candida albicans by Granulocyte Colony-Stimulating Factor (G-CSF) JID 179:1301-4, 1999

Gaviria JM, van Burik JH, Dale DC, and Root RK. Comparisons oflnterfem-y, Granulocyte Colony-Stimulating Factor, and Granulocy1e-y Macrophage Colony-Stimulating Factor for Priming Leukocyte-Mediated Hyphal Damage of Opportunistic Fungal Pathogens. JID 179:1038-41, 1999

Burack HI, Irby DM, Carline JD, Larson EB, and Root RK: Teaching Compassion and Respect. Attendings' Responses to Problematic Behavior. JGIM 14:49-55, 1999

Root RK, Gaviria JM, Grohskopf LA, and Barnes R. Successful Treatment ofRhinocerebral Zygomycosis: A Combined Strategy Approach. Clin Infect Dis 28:160-161, 1999

Nelson S, Heyder, AM, Stone J, Bergeron MG, Daugherty S, Peterson G, Fotheringham N, Welch W, Milwee S, Root R. A randomized controlled trial of filgrastim for the treatment of hospitalized patients Mith multilobar pneumonia. JID 182: 970-3, 2000

Park DR. Sherbin VL, Goodman MS, Root RK, et al. The Etiology of Community-Acquired Pneumonta at an Urban Public Hospital: The Influence of HIV Infection and Initial Severity of Illness. JID 184(3)::268-77, 2001

Nelson S, Welch W', Root RK, et al. Multicenter Double-blind, placebo-controlled Study of the Use of Filgrastim in Patients Hospitalized with Pneumonia and Severe Sepsis. Crit Care Med. (2):367- 73, 2003

1. Invited Editorials and Reviews
2. Adler LM and Root RK: Granulocyte transfusion therapy: Experimental basis and clinical applications. JAOA 76:595, 1977.
3. Root RK and Cohen MS: Microbicidal mechanisms of neutrophils and eosinophils. Reviews of Infection: Diseases 3:565-598, 1981.
4. Root RK: Host defenses against infection: importance of phagocytic mechanisms from the study of genetic disorders of leukocyte function. Bulletin of New York Academy of Medicine 58:669-680, 1982.
5. Root RK and Nation CL: Legislated Limits for Housestaff Training. Ant. Int. Med. 116:694-696, 1992.
   
6. Root RK, Dale DC: Granulocyte colony-stimulating factor and granulocyte-macrophange colony­ stimulating factor: comparisons and potential use in the treatment of infections in nonneutropenic patients J Infect Dis. 179(2):S342-52, 1998
7. Sheffield JVL, Root RK. Smoking and Pneumococcal Infection. NEJM:342;732-734, 2000
8. Stevens DL, Root RK, Rosen H, Dale DC: Differential white blood cell count: underutilized or overrate:d. Curr Opin Infect Dis. 13(3):205-207, :woo
9. Gaviria JM, Garrido SM, Root RK: Clinical use of granulocyte colony-stimulating factor in

infectious diseases. Curr Opin Infect Dis. 21:302-22, 2001

1. Other PuJJlications
2. Root RK, and Stossel TP: Functional comparison of Chediak-Higashi syndrome and chronic granulomatous disease leukocytes. The Fourth Conference on the Clinical Delineation of Birth Defects, Part SIV, Blood. The National Foundation March of Dimes, Williams and Wilkins, Baltimore, Maryland, 1972

, Miller ME and Root RK: Recurrent infections due to disorders of the inflammatory host defense. In Seminars in Medicine: An Audio-Visual Journal, Vol. 1, No. 3, November-December 1972, Williams and Wilkins Co., Baltimore, MD.

1. Root RK: Comparison of other defects of granulomatous disease. In The Phagocytic Cell in Host Resistance, Dayton (ed.), Raven Press, 1975.
2. Root RK: Fungal and parasitic infections. In Diagnosis of Treatable Diseases, Horowitz and Magee (eds.), Lea and Febiger, 1976.
3. : Enterococcal meningitis: Combined vancomycin and rifampin therapy. The American Journal of Medicine 68:449-451, 1980.
4. *Root RK, Molavi A, Metcalf J, Malech H, Isturiz RI: Interactions between antibiotics and neutrophils in the killing of staphylococci. The Journal of Clinical Investigation 67:247-249, 1981.
5. Cohen MS, Metcalf JA, and Root RK: Regulation of oxygen metabolism in human granulocytes: relationship between stimulus binding and oxidative response using plant lectins as probes. Blood 55:1003--1010, 1980.
6. Greene WH, Colclough L, Anton A, and Root RK: Lectin-dependent neutrophil-mediated cytotoxtcity against chicken erythrocytes: A model of non-myeloperoxidase mediated oxygen­ dependent killing by human neutrophils. Journal of Immunology 125:2727, 1980.
7. 54. Cohen MS, lsturiz RI, Malech HL, and Root RK: Fungal infection in chronic granulomatous disease: the importance of the phagocyte in defense against fungi. American Journal of Medicine 71:59-66. 1981.
8. Cohen MS, Ryan JL, and Root RK: The oxidative metabolism of thioglycollate elicited mouse peritorn al macrophages: the relationship between oxygen, superoxide and hydrogen peroxide and the effect of monolayer formation. Journal of Immunology 127:1007-1011, 1981.

Parry MF, Root RK, Metcalf JA, Delaney KK, Kaplow LS, and Ricar WJ: Myeloperoxidase deficiency: prevalence and clinical significance

1. Thier S, Henderson L, and Root RK: Renal transplantation: medical management of the transplant recipient. In Kidr , Brenner and Rector (eds.), W.B. Saunders, Philadelphia, PA, 1976.
2. Root RK and Metcalf JA: Superoxide and hydrogen peroxide formation by human granulocytes: interrelationships and activation mechanisms. In Movement. Metabolism and Bactericidal Mechanisms of Phagocytosis. (Eds.) Rossi F, Patriarca PL, and Romeo D, Piccin (Publisher), London, 1977,pp. 185-199.
   
3. Root RK and Hierholzer W: Infectious disease. In Clinical Pharmacology: Basic Principles in Therapeutics. (Ed.) Melmon and Morrelli. MacMillan, 1978.
4. Zakhireh B, Block LH, and Root RK: Neutrophil function and host resistance. Infection 7:2-12, 1979.
5. Root RK: Humoral immunity and complement in infection. In Principles and Practices of lnfectious Disease. (Eds.) Mandell GL, Douglas RG, Jr., and Bennett JE. Wiley and Sons, Inc. New York, NY, 1979.
6. Root RK: Polymorphonuclear leukocytes in host defense. In Microbiology.  1981.
7. Coleman DL and Root RK: Pulmonary infections in Southeast Asian refugees. Clinics in Chest Medicine 2:133-143, 1981.
8. Kliger AS, Maunder R, Reynolds H, and Root RK: Methanol intoxication. Medical Times 109:60- 73, 1981.
9. Root RK: The macrophage in host defense. In Microbiologv, (Ed.) Schelissinger D. American Society for Microbiology. Washington, D.C., 1981, pp. 176-180.
10. Ryan JL and Root RK: Activation of macrophages. In Microbiologv, (Ed.) Schelissinger D. American Society for Microbiology. Washington, D.C., 1982, pp. 370-373.
11. Yourtee EL and Root RK: Antibiotic-neutrophil interactions in microbial killing. Advances in Host Defense I:187-209, 1982.
12. Root RK: Genetic disorders of leukocyte function: What they tell us about normal antimicrobial mechanisms of human phagocytic cells. Klinische Wochenschrift 60:731-734, 1982.
13. Yourtee EL and Root RK: Effect of antibiotics on phagocyte-microbe interactions. In Contemporary Issm:s in Infectious Diseases. New Dimensions in Antimicrobial Therapv. (Eds.) Root RK and Sande: MA, Churchill Livingstone, Inc., New York, 1983, pp. 243-275.
14. Root RK: Host Defenses in the Human Neonate: Ontogeny, Role in Protection Against Infection, PossibiJiti,es for Augmentation During Sepsis. Mead Johnson Symposium in Perinatal and Developmental Medicine, December 5-9, 1982, Marco Island, Florida
15. Hickstein DD and Root RK: Polymorphonuclear leukocytes: function and role in sepsis. In Contemporarv Issues in Infectious Diseases. Septic Shock. (Eds.) Root RK and Sande MA, Churchill Livingstone, Inc., New York, 1985, pp. 61-82.
16. Root RK. Infectious diseases: pathogenetic mechanisms and host responses. In PathophysiologY (Eds.) Smith LH and Thier SO., Saunders, "Kew York, 1985, pp. 139-1 T2.
17. McGee Sand Root RK: Respiratory infections complicating immunodeficiency. Contemporarv Issues in Infectious Diseases: Respiratory Infections, Eds. Root RK, Hudson L, Sande MA. Churchill Livingstone, Inc., New York, 1985, p. 71-107.
18. Root RK and Ryan JL: Humoral Immunity and Complement. In Principles and Practice of Infectious Diseases. Eds. Mandell GL, Douglas, RG Jr, Bennett JE., 2nd Ed., J. Wiley and Sons, Inc.,NewYork,NewYork. 1985,p. 31-57.
19. Petersdorf RG and Root RK: Chills and Fever. In Harrison's Principles of Internal Medicine. Eds. Braumvald E, Is:selbacher KJ, PetersdorfRG, Wilson JD, Martin JB and Fauci AS. 11th Ed., McGraw-I-Iill, New York, New York, 1987, p. 50-57.
20. Petersdorf RG and Root RK: An Approach to Infectious Diseases. In Harrison's Principles of Internal Medicine. Eds. Braunwald E., Isselbacher JK, Petersdorf RG, Wilson JD, Martin JB and Fauci AS. 11th Ed., McGraw-Hill, New York, New York, 1987, p. 455-459.
21. Root RK: The Compromised Host. In Cecil's Textbook of Medicine. Eds. Wyngaarden JB, Smith LH, and Plum F. 18th Ed. W.B. Saunders, Philadelphia, Pa., 1988, p. 1529-1538.